She-Wolf The Last Sentinel — The plot revolves around young lovers Lyka Raymundo and Noah Ortega. Lyka is a young woman aspiring to be a fashion designer and works as a fashion assistant in the House of Elle. Her decision to pursue the arts is frowned upon by her Tita Clara Rivero because, according to her, it is not a practical choice.
Noah becomes a second lieutenant of the Philippine Army. During a crucial mission, he saves Don Manolo Sebastian and becomes involved in the battle between the Luna and the Waya.
Lyka's position as fashion assistant to Lady Elle is foreshadowed by the fact that she is believed to be the last hope of her fellow White Werewolves (a faction/clan of Filipino werewolves): "Ang Huling Bantay". It is through the House of Elle that Lyka crosses paths with Noah, Lady Elle's bodyguard and driver. Little does she know that he is actually her childhood friend, "Jay-Jay" who she thought was long dead. When Lyka and Noah finally meet and fall in love, something had to tear them apart. Something that Noah can never accept. The blossoming romance between the two is hindered by the presence of Gabrielle Dizon and Anton Rivero. Gabrielle is a deep-penetration agent who attempts to distract Noah while Anton is in love with Lyka and will do anything to prove his love.
There are two opposing groups in the story—the Luna and the Waya. The members of the Luna organization have a grudge against the werewolves while the Waya are the protectors of the Lobo (the werewolves), and they want them to co-exist harmoniously with normal humans.